東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ subject:"Bioengineering." ]

切換: 標籤 | MARC模式 | ISBD

Non-Penetrating Microelectrode Inter...

Oswalt, Denise.

FindBook

Google Book

Amazon

博客來

Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex./
作者:	Oswalt, Denise.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	129 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
標題:	Bioengineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10976061
ISBN:	9780438713253

Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex.
Oswalt, Denise.

Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 129 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--Arizona State University, 2018.

This item must not be added to any third party search indexes.

Growing understanding of the neural code and how to speak it has allowed for notable advancements in neural prosthetics. With commercially-available implantable systems with bi-directional neural communication on the horizon, there is an increasing imperative to develop high resolution interfaces that can survive the environment and be well tolerated by the nervous system under chronic use. The sensory encoding aspect optimally interfaces at a scale sufficient to evoke perception but focal in nature to maximize resolution and evoke more complex and nuanced sensations. Microelectrode arrays can maintain high spatial density, operating on the scale of cortical columns, and can be either penetrating or non-penetrating. The non-penetrating subset sits on the tissue surface without puncturing the parenchyma and is known to engender minimal tissue response and less damage than the penetrating counterpart, improving long term viability in vivo. Provided non-penetrating microelectrodes can consistently evoke perception and maintain a localized region of activation, non-penetrating micro-electrodes may provide an ideal platform for a high performing neural prosthesis; this dissertation explores their functional capacity. The scale at which non-penetrating electrode arrays can interface with cortex is evaluated in the context of extracting useful information. Articulate movements were decoded from surface microelectrode electrodes, and additional spatial analysis revealed unique signal content despite dense electrode spacing. With a basis for data extraction established, the focus shifts towards the information encoding half of neural interfaces. Finite element modeling was used to compare tissue recruitment under surface stimulation across electrode scales. Results indicated charge density-based metrics provide a reasonable approximation for current levels required to evoke a visual sensation and showed tissue recruitment increases exponentially with electrode diameter. Micro-scale electrodes (0.1 - 0.3 mm diameter) could sufficiently activate layers II/III in a model tuned to striate cortex while maintaining focal radii of activated tissue. In vivo testing proceeded in a nonhuman primate model. Stimulation consistently evoked visual percepts at safe current thresholds. Tracking perception thresholds across one year reflected stable values within minimal fluctuation. Modulating waveform parameters was found useful in reducing charge requirements to evoke perception. Pulse frequency and phase asymmetry were each used to reduce thresholds, improve charge efficiency, lower charge per phase - charge density metrics associated with tissue damage. No impairments to photic perception were observed during the course of the study, suggesting limited tissue damage from array implantation or electrically induced neurotoxicity. The subject consistently identified stimulation on closely spaced electrodes (2 mm center-to-center) as separate percepts, indicating sub-visual degree discrete resolution may be feasible with this platform. Although continued testing is necessary, preliminary results supports epicortical microelectrode arrays as a stable platform for interfacing with neural tissue and a viable option for bi-directional BCI applications.

ISBN: 9780438713253Subjects--Topical Terms:

657580
Bioengineering.

Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex.
LDR:04531nmm a2200337 4500 001 2207238
005 20190916101806.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780438713253
035 $a (MiAaPQ)AAI10976061
035 $a (MiAaPQ)asu:18323
035 $a AAI10976061
040 $a MiAaPQ $c MiAaPQ
100 1 $a Oswalt, Denise. $3 3434195
245 1 0 $a Non-Penetrating Microelectrode Interfaces for Cortical Neuroprosthetic Applications With a Focus on Sensory Encoding: Feasibility and Chronic Performance in Striate Cortex.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 129 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Greger, Bradley.
502 $a Thesis (Ph.D.)--Arizona State University, 2018.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a Growing understanding of the neural code and how to speak it has allowed for notable advancements in neural prosthetics. With commercially-available implantable systems with bi-directional neural communication on the horizon, there is an increasing imperative to develop high resolution interfaces that can survive the environment and be well tolerated by the nervous system under chronic use. The sensory encoding aspect optimally interfaces at a scale sufficient to evoke perception but focal in nature to maximize resolution and evoke more complex and nuanced sensations. Microelectrode arrays can maintain high spatial density, operating on the scale of cortical columns, and can be either penetrating or non-penetrating. The non-penetrating subset sits on the tissue surface without puncturing the parenchyma and is known to engender minimal tissue response and less damage than the penetrating counterpart, improving long term viability in vivo. Provided non-penetrating microelectrodes can consistently evoke perception and maintain a localized region of activation, non-penetrating micro-electrodes may provide an ideal platform for a high performing neural prosthesis; this dissertation explores their functional capacity. The scale at which non-penetrating electrode arrays can interface with cortex is evaluated in the context of extracting useful information. Articulate movements were decoded from surface microelectrode electrodes, and additional spatial analysis revealed unique signal content despite dense electrode spacing. With a basis for data extraction established, the focus shifts towards the information encoding half of neural interfaces. Finite element modeling was used to compare tissue recruitment under surface stimulation across electrode scales. Results indicated charge density-based metrics provide a reasonable approximation for current levels required to evoke a visual sensation and showed tissue recruitment increases exponentially with electrode diameter. Micro-scale electrodes (0.1 - 0.3 mm diameter) could sufficiently activate layers II/III in a model tuned to striate cortex while maintaining focal radii of activated tissue. In vivo testing proceeded in a nonhuman primate model. Stimulation consistently evoked visual percepts at safe current thresholds. Tracking perception thresholds across one year reflected stable values within minimal fluctuation. Modulating waveform parameters was found useful in reducing charge requirements to evoke perception. Pulse frequency and phase asymmetry were each used to reduce thresholds, improve charge efficiency, lower charge per phase - charge density metrics associated with tissue damage. No impairments to photic perception were observed during the course of the study, suggesting limited tissue damage from array implantation or electrically induced neurotoxicity. The subject consistently identified stimulation on closely spaced electrodes (2 mm center-to-center) as separate percepts, indicating sub-visual degree discrete resolution may be feasible with this platform. Although continued testing is necessary, preliminary results supports epicortical microelectrode arrays as a stable platform for interfacing with neural tissue and a viable option for bi-directional BCI applications.
590 $a School code: 0010.
650 4 $a Bioengineering. $3 657580
650 4 $a Neurosciences. $3 588700
690 $a 0202
690 $a 0317
710 2 $a Arizona State University. $b Biomedical Engineering. $3 3347764
773 0 $t Dissertations Abstracts International $g 80-06B.
790 $a 0010
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10976061