東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ subject:"Enantiomers." ]

切換: 標籤 | MARC模式 | ISBD

Development of chemistry-based scree...

Noguchi, Taro.

FindBook

Google Book

Amazon

博客來

Development of chemistry-based screening platform for access to mirror-image library of natural products

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of chemistry-based screening platform for access to mirror-image library of natural products/ by Taro Noguchi.
作者:	Noguchi, Taro.
出版者:	Singapore :Springer Singapore : : 2018.,
面頁冊數:	xiv, 80 p. :ill., digital ;24 cm.
內容註:	Introduction -- Development of a Mirror-image Screening Process by Using Synthetic Proteins -- Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems -- Conclusions.
Contained By:	Springer eBooks
標題:	Enantiomers. -
電子資源:	http://dx.doi.org/10.1007/978-981-10-6623-8
ISBN:	9789811066238

Development of chemistry-based screening platform for access to mirror-image library of natural products
Noguchi, Taro.

Development of chemistry-based screening platform for access to mirror-image library of natural products[electronic resource] /by Taro Noguchi. - Singapore :Springer Singapore :2018. - xiv, 80 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Development of a Mirror-image Screening Process by Using Synthetic Proteins -- Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems -- Conclusions.

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

ISBN: 9789811066238

Standard No.: 10.1007/978-981-10-6623-8doiSubjects--Topical Terms:

1060597
Enantiomers.

LC Class. No.: QP517.C57

Dewey Class. No.: 543.17

Development of chemistry-based screening platform for access to mirror-image library of natural products
LDR:02941nmm a2200325 a 4500 001 2132087
003 DE-He213
005 20180717093552.0
006 m d
007 cr nn 008maaau
008 181005s2018 si s 0 eng d
020 $a 9789811066238 $q (electronic bk.)
020 $a 9789811066221 $q (paper)
024 7 $a 10.1007/978-981-10-6623-8 $2 doi
035 $a 978-981-10-6623-8
040 $a GP $c GP
041 0 $a eng
050 4 $a QP517.C57
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
082 0 4 $a 543.17 $2 23
090 $a QP517.C57 $b N778 2018
100 1 $a Noguchi, Taro. $3 3298277
245 1 0 $a Development of chemistry-based screening platform for access to mirror-image library of natural products $h [electronic resource] / $c by Taro Noguchi.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2018.
300 $a xiv, 80 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Development of a Mirror-image Screening Process by Using Synthetic Proteins -- Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems -- Conclusions.
520 $a This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.
650 0 $a Enantiomers. $3 1060597
650 0 $a Natural products $x Spectra. $3 3298278
650 0 $a Analytical biochemistry. $3 586155
650 1 4 $a Chemistry. $3 516420
650 2 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Organic Chemistry. $3 890856
650 2 4 $a Pharmaceutical Sciences/Technology. $3 1001579
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 1314442
856 4 0 $u http://dx.doi.org/10.1007/978-981-10-6623-8
950 $a Chemistry and Materials Science (Springer-11644)