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Transthoracic Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force-based Ultrasound Methods.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Transthoracic Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force-based Ultrasound Methods./
作者:	Kakkad, Vaibhav R.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	209 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-07, Section: B.
Contained By:	Dissertations Abstracts International80-07B.
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10935299
ISBN:	9780438802834

Transthoracic Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force-based Ultrasound Methods.
Kakkad, Vaibhav R.

Transthoracic Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force-based Ultrasound Methods. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 209 p.

Source: Dissertations Abstracts International, Volume: 80-07, Section: B.

Thesis (Ph.D.)--Duke University, 2018.

This item must not be sold to any third party vendors.

Heart failure is one of the most common cardiac disorders and is projected to increase in prevalence over the next few decades. It can arise from a wide variety of root causes such as coronary artery disease, hypertension, cardiomyopathy, or cardiotoxicity and can manifest as systolic and/or diastolic dysfunction. Traditionally, its diagnosis has been based on monitoring qualitative changes in cardiac structure, such as chamber geometry and wall motion patterns, or quantitative changes in indices of cardiac function, such as the blood flow velocities and ventricular ejection fraction. These parameters are assessed in clinical settings using medical imaging modalities like ultrasound and magnetic resonance imaging. Recent research into cardiac pathophysiology has indicated that the progression of cardiac disease is often accompanied by changes in the mechanical properties of cardiac muscle. Interrogation of these changes could be used to gain useful diagnostic insight into the etiology of heart failure. Acoustic radiation force (ARF)-based techniques, such as acoustic radiation force impulse imaging and shear wave elasticity imaging, provide the means to measure mechanical properties of soft tissues using ultrasound. They operate on the principle that ultrasound can be used to remotely generate as well as track micron-level vibrations in the body and thus derive mechanical properties such as tissue stiffness. ARFI and SWEI have previously been shown to capture dynamic changes in myocardial stiffness in Langendorff set-ups, open-chest experiments, and intracardiac settings. This dissertation explores the challenges and opportunities of implementing acoustic radiation force-based methods for noninvasive applications via transthoracic imaging windows. Transthoracic imaging of the heart using ultrasound can be challenging for a number of reasons. The two main sources of signal degradation that were hypothesized to impact ARFI and SWEI in this environment are acoustic clutter and intrinsic tissue motion. Acoustic clutter refers to incorrectly localized echoes which lead to the degradation of target conspicuity, border delineation, and image quality. Intrinsic tissue motion, on the other hand, impedes the ability to accurately measure the ARF-induced motion and consequently affects the estimation of tissue stiffness. The work presented herein focuses on quantifying the level of both sources of signal degradation under in vivo imaging conditions and evaluating the effectiveness of strategies to minimize their impact. Lastly, the feasibility of tracking dynamic myocardial stiffness through the cardiac cycle via transthoracic imaging windows on human volunteers was investigated. Harmonic imaging is often used to suppress acoustic clutter in clinical settings. Clutter levels are also closely tied to the choice of beamforming configuration used. Quantifying the impact of harmonic imaging and transmit beamforming on acoustic clutter, under in vivo transthoracic imaging conditions is therefore important. Clutter level, for a given imaging scenario, was quantified using contrast between the cardiac chambers and the interventricular septum. Substantial variations in clutter levels were observed across as well as within volunteers. Harmonic imaging had a measurable impact in suppressing clutter under both the plane wave and focused configurations. However, even in the optimal configuration, clutter levels varied over a broad range. These results suggest that acoustic clutter, while consistently lowered through the use of harmonic imaging, is still likely to be a major detriment to transthoracic measurement of myocardial stiffness. The heart exhibits complex and rapid three-dimensional motion; this could be a dominant confounder when attempting to measure micron-level ARF-induced displacements. Intrinsic cardiac motion of the interventricular septum, as observed through the parasternal long- and short-axis views, was analyzed in both the time- and frequency-domain. Two types of motion filters, frequency-based and recovery-based were compared to assess their ability to separate the axial component of cardiac motion from the ARF-induced motion. The effect of non-axial cardiac motion on speckle decorrelation was quantified using temporal coherence and related to the uncertainty of axial displacement estimation or jitter. High-pass filters with cutoffs >75 Hz and quadratic polynomial filters were found to be equally effective at compensating for axial tissue motion. While high-pass filters are independent of a recovery-time assumption, they introduce a downward bias to measured ARF-induced motion; this bias increases with cutoff frequency. Temporal coherence was empirically related to measured displacement estimation jitter. At end-diastole, temporal coherence was high and jitter was low. In other phases of the cardiac cycle, however, jitter was found to increase dramatically with the span of the temporal window over which it was computed. Jitter for short spans, 2ms, was found to be in the range of 2-8 μm, However, for spans of 10 ms, it could be as high as 10-20 μm. (Abstract shortened by ProQuest.).

ISBN: 9780438802834Subjects--Topical Terms:

3172799
Medical imaging.

Transthoracic Measurement of Dynamic Myocardial Stiffness Using Acoustic Radiation Force-based Ultrasound Methods.
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520 $a Heart failure is one of the most common cardiac disorders and is projected to increase in prevalence over the next few decades. It can arise from a wide variety of root causes such as coronary artery disease, hypertension, cardiomyopathy, or cardiotoxicity and can manifest as systolic and/or diastolic dysfunction. Traditionally, its diagnosis has been based on monitoring qualitative changes in cardiac structure, such as chamber geometry and wall motion patterns, or quantitative changes in indices of cardiac function, such as the blood flow velocities and ventricular ejection fraction. These parameters are assessed in clinical settings using medical imaging modalities like ultrasound and magnetic resonance imaging. Recent research into cardiac pathophysiology has indicated that the progression of cardiac disease is often accompanied by changes in the mechanical properties of cardiac muscle. Interrogation of these changes could be used to gain useful diagnostic insight into the etiology of heart failure. Acoustic radiation force (ARF)-based techniques, such as acoustic radiation force impulse imaging and shear wave elasticity imaging, provide the means to measure mechanical properties of soft tissues using ultrasound. They operate on the principle that ultrasound can be used to remotely generate as well as track micron-level vibrations in the body and thus derive mechanical properties such as tissue stiffness. ARFI and SWEI have previously been shown to capture dynamic changes in myocardial stiffness in Langendorff set-ups, open-chest experiments, and intracardiac settings. This dissertation explores the challenges and opportunities of implementing acoustic radiation force-based methods for noninvasive applications via transthoracic imaging windows. Transthoracic imaging of the heart using ultrasound can be challenging for a number of reasons. The two main sources of signal degradation that were hypothesized to impact ARFI and SWEI in this environment are acoustic clutter and intrinsic tissue motion. Acoustic clutter refers to incorrectly localized echoes which lead to the degradation of target conspicuity, border delineation, and image quality. Intrinsic tissue motion, on the other hand, impedes the ability to accurately measure the ARF-induced motion and consequently affects the estimation of tissue stiffness. The work presented herein focuses on quantifying the level of both sources of signal degradation under in vivo imaging conditions and evaluating the effectiveness of strategies to minimize their impact. Lastly, the feasibility of tracking dynamic myocardial stiffness through the cardiac cycle via transthoracic imaging windows on human volunteers was investigated. Harmonic imaging is often used to suppress acoustic clutter in clinical settings. Clutter levels are also closely tied to the choice of beamforming configuration used. Quantifying the impact of harmonic imaging and transmit beamforming on acoustic clutter, under in vivo transthoracic imaging conditions is therefore important. Clutter level, for a given imaging scenario, was quantified using contrast between the cardiac chambers and the interventricular septum. Substantial variations in clutter levels were observed across as well as within volunteers. Harmonic imaging had a measurable impact in suppressing clutter under both the plane wave and focused configurations. However, even in the optimal configuration, clutter levels varied over a broad range. These results suggest that acoustic clutter, while consistently lowered through the use of harmonic imaging, is still likely to be a major detriment to transthoracic measurement of myocardial stiffness. The heart exhibits complex and rapid three-dimensional motion; this could be a dominant confounder when attempting to measure micron-level ARF-induced displacements. Intrinsic cardiac motion of the interventricular septum, as observed through the parasternal long- and short-axis views, was analyzed in both the time- and frequency-domain. Two types of motion filters, frequency-based and recovery-based were compared to assess their ability to separate the axial component of cardiac motion from the ARF-induced motion. The effect of non-axial cardiac motion on speckle decorrelation was quantified using temporal coherence and related to the uncertainty of axial displacement estimation or jitter. High-pass filters with cutoffs >75 Hz and quadratic polynomial filters were found to be equally effective at compensating for axial tissue motion. While high-pass filters are independent of a recovery-time assumption, they introduce a downward bias to measured ARF-induced motion; this bias increases with cutoff frequency. Temporal coherence was empirically related to measured displacement estimation jitter. At end-diastole, temporal coherence was high and jitter was low. In other phases of the cardiac cycle, however, jitter was found to increase dramatically with the span of the temporal window over which it was computed. Jitter for short spans, 2ms, was found to be in the range of 2-8 μm, However, for spans of 10 ms, it could be as high as 10-20 μm. (Abstract shortened by ProQuest.).
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