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Endocannabinoid signaling in social ...

Wei, Don.

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Endocannabinoid signaling in social behavior.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Endocannabinoid signaling in social behavior./
作者:	Wei, Don.
面頁冊數:	117 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.
Contained By:	Dissertation Abstracts International77-08B(E).
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10046744
ISBN:	9781339563633

Endocannabinoid signaling in social behavior.
Wei, Don.

Endocannabinoid signaling in social behavior. - 117 p.

Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.

Thesis (Ph.D.)--University of California, Irvine, 2016.

Many animal species are social, which in many ways is essential for their survival. The neural substrates of social behavior are largely unknown, but studies on marijuana have hinted at a role for endocannabinoid signaling. We investigated this possibility using a combination of pharmacological and genetic approaches, with social place preference and social approach as readouts for social reward and social interest, respectively. The main findings of this work are: (i) oxytocin neurons in the hypothalamus recruits anandamide-mediated endocannabinoid signaling in the nucleus accumbens to regulate social reward; (ii) the endocannabinoid 2-AG is also involved in social reward but with key differences, including being generalizable to other rewards; (iii) inhibiting enzyme-mediated anandamide hydrolysis to promote its signaling may offer a viable therapeutic approach for autism-related social impairment. These findings provide important insights for larger questions in social neuroscience, including mechanisms of recruiting the endocannabinoid system, social modulation, and social development. They suggest that targeting endocannabinoid signaling may be a worthwhile approach in the treatment of social impairment, which is involved in most mental illnesses.

ISBN: 9781339563633Subjects--Topical Terms:

588700
Neurosciences.

Endocannabinoid signaling in social behavior.
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